生物
机制(生物学)
巨噬细胞
细胞生物学
T细胞
平衡
细胞
免疫学
免疫系统
遗传学
认识论
哲学
体外
作者
Siamon Gordon,Fernando O. Martínez
出处
期刊:Immunity
[Elsevier]
日期:2010-05-01
卷期号:32 (5): 593-604
被引量:3349
标识
DOI:10.1016/j.immuni.2010.05.007
摘要
The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set to gain deeper insights into the role of alternatively activated macrophages in immunobiology.
科研通智能强力驱动
Strongly Powered by AbleSci AI