同源盒
生物
神经嵴
神经外胚层
神经管
HNF1B型
同源框A1
器官发生
神经板
同源框蛋白Nkx-2.5
CDX2
神经发育
基因
脊椎动物
间脑
DLX5型
神经发生
遗传学
6号乘客
TBX1型
转录因子
神经科学
中胚层
基因表达
中枢神经系统
发起人
胚胎
胚胎干细胞
作者
Casto Ramos,Benoît Robert
标识
DOI:10.1016/j.tig.2005.09.001
摘要
The involvement of Msx homeobox genes in skull and tooth formation has received a great deal of attention. Recent studies also indicate a role for the msh/Msx gene family in development of the nervous system. In this article, we discuss the functions of these transcription factors in neural-tissue organogenesis. We will deal mainly with the interactions of the Drosophila muscle segment homeobox (msh) gene with other homeobox genes and the repressive cascade that leads to neuroectoderm patterning; the role of Msx genes in neural-crest induction, focusing especially on the differences between lower and higher vertebrates; their implication in patterning of the vertebrate neural tube, particularly in diencephalon midline formation. Finally, we will examine the distinct activities of Msx1, Msx2 and Msx3 genes during neurogenesis, taking into account their relationships with signalling molecules such as BMP.
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