A review on synthetic study and biological activities of tetrahydropyrimidinone derivatives

The process of drug discovery involves the identification, synthesis, characterization, screening, assay and development of new chemical entities that are suitable for medical and pharmaceutical use.2-thioxo-1, 2, 3, 4-tetrahydropyrimidine (THPM) are heterocyclic compound & represents are markable pharmacological efficient moieties and are with wide range of therapeutic properties.Synthetically they were synthesized using Multi-component reactions like Biginelli reaction or either microwave and conventional methods, having a multiple benefits of the time consuming and get high yield.In this review, we highlight recent developments on THPMs and recently developed as antimicrobial, anticancer, antiinflammatory, analgesic, antifungal, antibacterial, anti-tubercular, antihypertensive, analgesic, anticonvulsant, antioxidant, etc. given a potent biological and pharmacological activity.