催化作用
产量(工程)
胺化
组合化学
烷基化
药物化学
有机化学
钯
作者
Junchi Zhang,Fuqiang Zhu,Guanghui Tian,Xiangrui Jiang,Jingshan Shen
标识
DOI:10.1021/acs.oprd.9b00556
摘要
A safe and efficient synthesis of 6-chloro-5-methylpyridin-2-amine, a key intermediate for lumacaftor, is described, which avoids the utilization of peroxide. In this four-step sequence, starting f...
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