突触发生
生物
神经发生
神经科学
胶质发生
串扰
微泡
小RNA
细胞生物学
神经系统
神经发育
信号转导
信号灯
神经干细胞
基因
干细胞
光学
物理
生物化学
受体
作者
Ana Rita Gomes,Nasim Bahram Sangani,Tiago G. Fernandes,Maria Margarida Diogo,Leopold Curfs,Chris Reutelingsperger
摘要
The central nervous system (CNS) is the most complex structure in the body, consisting of multiple cell types with distinct morphology and function. Development of the neuronal circuit and its function rely on a continuous crosstalk between neurons and non-neural cells. It has been widely accepted that extracellular vesicles (EVs), mainly exosomes, are effective entities responsible for intercellular CNS communication. They contain membrane and cytoplasmic proteins, lipids, non-coding RNAs, microRNAs and mRNAs. Their cargo modulates gene and protein expression in recipient cells. Several lines of evidence indicate that EVs play a role in modifying signal transduction with subsequent physiological changes in neurogenesis, gliogenesis, synaptogenesis and network circuit formation and activity, as well as synaptic pruning and myelination. Several studies demonstrate that neural and non-neural EVs play an important role in physiological and pathological neurodevelopment. The present review discusses the role of EVs in various neurodevelopmental disorders and the prospects of using EVs as disease biomarkers and therapeutics.
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