Dirhodium(II)‐Catalyzed Cyclopropanation of Alkyne‐Containing α‐Diazoacetates for the Synthesis of Cycloalkynes

Abstract An efficient dirhodium(II)‐catalyzed macrocyclization reaction of alkyne‐containing diazoacetates through intramolecular metal carbene cyclopropanation is described. This method provides a variety of 12‐ to 22‐membered macrocyclic alkynes, which incorporate ortho ‐aryl, cyclopropane, and cyclopropene units, in good to excellent yields under mild reaction conditions. magnified image