A New Synthesis of Streptomyces Lactones by 1,3-Dipolar Cycloaddition

The cycloaddition of nitrones (4) to propene, followed by sequential treatment with methyl trifluoromethanesulfonate, H 2 -Pd/C, and m-chloroperbenzoic acid, is shown to provide a general method for the preparation of a variety of volatile streptomyces lactones