Protective Effects of Hydroalcoholic Extract of Boerhaavia Diffusa Linn Against Cisplatin Induced Nephrotoxicity in Rats

The present studies, the cisplatin treated animals showed a significant increase in blood urea, blood urea nitrogen and serum creatinine. As shown in [Table no:4] serum creatinine, Blood urea nitrogen (BUN), and blood urea levels were significantly higher after 72 h respectively, after administration of single dose of cisplatin when compared to the control group. The pre-treatment with Hydro alcoholic extract of Boerhaavia diffusa (HAEBD) p.o. significantly (P < 0.01) lowered the elevated serum urea creatinine, and Blood urea nitrogen (BUN). When compared to the cisplatin group. The pre-treatment with silymarin showed a marked decrease in concentrations of blood urea, serum creatinine, Blood urea nitrogen and alkaline phosphatise, it was shown that cisplatin treatment induced renal damage and pretreatment with hydro alcoholic extract of Boerhaavia diffusa (HAEBD) provided protective effect against this cisplatin-induced nephrotoxicity. However, before concluding a potential usefulness of hydro alcoholic extract of Boerhaavia diffusa (HAEBD) as adjunct to the cisplatin therapy, further clinical investigation is needed.