化学
质谱法
电离
样品制备
色谱法
离子源
分析化学(期刊)
环境电离
热电离质谱法
大气压激光电离
直接电子电离液相色谱-质谱联用界面
化学电离
热电离
大气压化学电离
质谱
质谱成像
作者
Yanbing Zhai,Siyu Liu,Lijuan Gao,Lili Hu,Wei Xu
标识
DOI:10.1021/acs.analchem.7b05366
摘要
With improved performances, miniature mass spectrometers are becoming suitable for more practical applications. At the same time, the coupling of an approximate ionization source is essential in terms of minimizing sample preparation and broadening the range of samples that could be analyzed. In this study, an atmospheric pressure laserspray ionization (AP-LSI) source was coupled with our home developed miniature ion trap mass spectrometer. The whole system is compact in size, and biological samples could be directly analyzed with minimum sample preparation. Direct detections of peptides, proteins, drugs in whole blood, and urine could be achieved with high sensitivity. The analyses of tissue sections were demonstrated, and different regions in a tissue section could be differentiated based on their lipid profiles. Results suggest that the coupling of AP-LSI with miniature mass spectrometer is a powerful technique, which could potentially benefit target molecule analysis in biological and medical applicat...
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