The Research Progress for Ghrelin, CGRP and NT on Gastrointestinal Function

The gastrointestinal tract is a largest hormone secretion organ,it is the most abundant source of regulation peptides. Gastrointestinal hormones are very important to gastrointestinal function,they regulate the movement,secretory,absorptive and other functions with the nervous system.Ghrelin,CGRP and NT are gastrointestinal hormone of representative which are newly discovered in recent years.Ghrelin is mainly produced by stomach organization, it can promote gastrointestinal peristalsis and promote the gastric acid secretion these effects are made by the vagus nerve mediated.Ghrelin can also protect the digestive tract mucosal.CGRP is widely distributed in the central and peripheral nervous system, it can regulate gastrointestinal blood flow, gastric secretion and gastric bowel movement.At present,the scholars generally agree that this biological effect of CGRP is plied through the NO and PG mediation.NT is widely distributed in the brain and the gastrointestinal tract and other organization, it is secreted by the intestinal N cell, it can inhibit gastric bowel movement, it also can protect the gastrointestinal mucosa cellss. We summarized the research for Ghrelin, CGRP, NT on gastrointestinal function in recent years in this paper.