Dissecting stroke for anti-VWF therapeutics

In this issue of Blood, Denorme et al report on a potent thrombolytic activity of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) that restores the blood flow of acutely occluded middle cerebral artery (MCA) in a mouse model of stroke.1