脂肪组织
脂肪细胞
白色脂肪组织
脂肪组织巨噬细胞
细胞生物学
营养过剩
3T3-L1
共焦显微镜
生物
化学
内分泌学
肥胖
作者
Gabriel Martinez-Santibanez,Kae Won Cho,Carey N. Lumeng
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2014-01-01
卷期号:: 17-30
被引量:41
标识
DOI:10.1016/b978-0-12-411619-1.00002-1
摘要
Adipose tissue is composed of a variety of cell types that include mature adipocytes, endothelial cells, fibroblasts, adipocyte progenitors, and a range of inflammatory leukocytes. These cells work in concert to promote nutrient storage in adipose tissue depots and vary widely based on location. In addition, overnutrition and obesity impart significant changes in the architecture of adipose tissue that are strongly associated with metabolic dysfunction. Recent studies have called attention to the importance of adipose tissue microenvironments in regulating adipocyte function and therefore require techniques that preserve cellular interactions and permit detailed analysis of three-dimensional structures in fat. This chapter summarizes our experience with the use of laser scanning confocal microscopy for imaging adipose tissue in rodents.
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