TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis

We show, for the first time, that TRAK2 is a novel regulator of LXR-mediated ABCA1 expression, cholesterol efflux, and HDL biogenesis. TRAK2 may therefore be an important target in the development of anti-atherosclerotic therapies.