Rational Design of a Dual-Layered Metal–Organic Framework Nanostructure for Enhancing the Cell Imaging of Molecular Beacons

. Therefore, efficient and accurate intracellular MDR1 mRNA imaging was realized with UiO66-MB-ZIF8. This work presented a new method for the rational regulation of the intracellular fate of MOF-based nanoprobes and will facilitate the further development of hierarchical MOF nanoprobes for analytical applications.