载脂蛋白B
可欣
脂肪肝
内分泌学
内科学
内质网
脂蛋白
脂质代谢
生物
化学
胆固醇
生物化学
低密度脂蛋白受体
医学
疾病
作者
Vatsal Sachan,Maïlys Le Dévéhat,Anna Roubtsova,Rachid Essalmani,Jean-Francois Laurendeau,Damien Garçon,Delia Susan‐Resiga,Stéphanie Duval,Sahar Mikaeeli,Josée Hamelin,Alexandra Evagelidis,Michael Chong,Guillaume Paré,Elizabeta Chernetsova,Zu‐Hua Gao,Isabelle Robillard,Matthieu Ruiz,Vincent Quoc‐Huy Trinh,Jennifer L. Estall,May Faraj
标识
DOI：10.1016/j.metabol.2023.155736
摘要
Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. We associated the known PCSK7 gain-of-function non-coding SNP rs236918 with higher levels of plasma apolipoprotein B (apoB) and the loss-of-function coding variant p.Pro777Leu (SNP rs201598301) with lower apoB and TG. Herein, we aimed to unravel the in vivo role of liver PCSK7.
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(2025-6-4)
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