化学
氢胺化
铱
三氟甲磺酸
马尔科夫尼科夫法则
烯烃
六氟磷酸盐
亲核细胞
光化学
胺气处理
阳离子聚合
反应性(心理学)
三氟甲磺酸
药物化学
组合化学
分子内力
有机化学
催化作用
区域选择性
离子液体
医学
替代医学
病理
作者
Eric Geunes,Jonathan M. Meinhardt,Emily J Wu,Robert R. Knowles
摘要
We report a light-driven method for the intermolecular anti-Markovnikov hydroamination of alkenes with primary heteroaryl amines. In this protocol, electron transfer between an amine substrate and an excited-state iridium photocatalyst affords an aminium radical cation (ARC) intermediate that undergoes C-N bond formation with a nucleophilic alkene. Integral to reaction success is the electronic character of the amine, wherein increasingly electron-deficient heteroaryl amines generate increasingly reactive ARCs. Counteranion-dependent reactivity is observed, and iridium triflate photocatalysts are employed in place of conventional iridium hexafluorophosphate complexes. This method exhibits broad functional group tolerance across 55 examples of N-alkylated products derived from pharmaceutically relevant heteroaryl amines.
科研通智能强力驱动
Strongly Powered by AbleSci AI