材料科学
骨整合
涂层
无定形磷酸钙
钛
模拟体液
无定形固体
明胶
化学工程
复合数
生物相容性
复合材料
钙
植入
化学
有机化学
扫描电子显微镜
冶金
医学
外科
工程类
作者
Yuanyi Feng,Di Wu,Jennifer Knaus,Sascha Keßler,Bing Ni,Zongkun Chen,Johnathan Avaro,Rui Xiong,Helmut Cölfen,Zuolin Wang
标识
DOI:10.1002/adhm.202203411
摘要
Abstract Biocompatible and bio‐active coatings can enhance and accelerate osseointegration via chemical binding onto substrates. Amorphous calcium phosphate (ACP) has been shown as a precursor to achieve mineralization in vertebrates and invertebrates under the control of biological macromolecules. This work presents a simple bioinspired Gelatin‐CaPO 4 (Gel‐CaP) composite coating on titanium surfaces to improve osseointegration. The covalently bound Gel‐CaP composite is characterized as an ACP‐Gel compound via SEM, FT‐IR, XRD, and HR‐TEM. The amorphous compound coating exhibits a nanometer range thickness and improved elastic modulus, good wettability, and nanometric roughness. The amount of grafted carboxyl groups and theoretical thickness of the coatings are also investigated. More importantly, MC3T3 cells, an osteoblast cell line, show excellent cell proliferation and adhesion on the Gel‐CaP coating. The level of osteogenic genes is considerably upregulated on Ti with Gel‐CaP coatings compared to uncoated Ti, demonstrating that Gel‐CaP coatings possess a unique osteogenic ability. To conclude, this work offers a new perspective on functional, bioactive titanium coatings, and Gel‐CaP composites can be a low‐cost and promising candidate in bone regeneration.
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