Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia

Abstract We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.