Portable Device for Wound Care: An Electrosprayable Zinc Basic Salt‐Tranexamic Acid Nanohybrid System

ABSTRACT Portable, point‐of‐care wound dressings that combine rapid hemostasis with pro‐regenerative cues are a clinical priority. We report two handy electrospinning strategies that integrate tranexamic acid–intercalated zinc basic salts (TXA–ZBS, via co‐precipitation) with polycaprolactone (PCL) nanofibers: i) embedded (TXA–ZBS/PCL), formed by blending TXA–ZBS into the PCL spinning solution, and ii) surface‐coated (TXA–ZBS@PCL), produced by electrospinning TXA–ZBS onto preformed PCL nanofiber mats. Both architectures preserve the mechanical integrity and conformal, spray‐on deployability of PCL while enabling TXA delivery at the wound interface with concurrent Zn 2 ⁺ release. In head‐to‐head testing, TXA–ZBS@PCL provided greater cumulative TXA availability with sustained, diffusion/ion‐exchange–governed kinetics, consistent with direct aqueous access to surface‐deposited TXA–ZBS, whereas TXA–ZBS/PCL exhibited a more diffusion‐limited profile due to the polymer barrier. In vitro and in vivo wound models showed that the coated architecture supported faster hemostatic responses and improved wound‐closure metrics relative to the embedded format. Taken together, these results identify surface‐coated TXA–ZBS@PCL as the preferred design for localized, surface‐constrained hemostasis, while the embedded configuration offers a more restricted release option when deeper diffusion is not desired. The comparative framework presented here guides selection of architecture for next‐generation, handy portable wound device.