Amphiphilic Bioactive Filler for Acrylic Bone Cement to Enhance Its Cell Adhesion

Bioactive amphiphilic raspberry particles (BRPs) were proposed to addressing the challenge in cement-bone interface non-integration that was often taking place when poly(methyl methacrylate) (PMMA) bone cements are used. BRPs were designed to have surface patches with different functions, some of which are bioactive to promote bonding to bone and the rest are hydrophobic to promote well compatibility with PMMA matrix. With Pickering emulsion polymerization plus post-modification on surface, such functional particles have been successfully prepared and the composite cements (BRP-PMMA composite cements) were indeed found to promote bone related cell adhesion, while not to sacrifice any of the virtues of the conventional PMMA bone cements.