细胞毒性T细胞
免疫学
T细胞
半抗原
生物
抗原
免疫系统
体外
生物化学
作者
L D Butler,Jacques M. Chiller
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:1983-10-01
卷期号:131 (4): 1663-1669
被引量:3
标识
DOI:10.4049/jimmunol.131.4.1663
摘要
The generation of cytotoxic T cell responses requires the interaction of a network of immunocompetent cells. Within this network, a dynamic balance of positive and negative immunoregulatory cells and their products modulate the cytotoxic T cell response. We have developed protocols which shift the balance to favor negative immunoregulation and thus result in antigen-specific unresponsiveness. In this report, a variety of approaches have been utilized to examine the effects of acute and chronic tolerance protocols on specific T cell subsets, namely amplifier helper T cells and precursor cytotoxic T cells. The results to be detailed show differential effects on these T cell subsets which are related to the tolerance protocol employed and the strains of mice tested.
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