In pursuit of beautiful, clean, and easing the control platform of numerous buttons, in-vehicle tough screens are arising. However, many studies have shown that, in-vehicle secondary tasks adversely affect driving safety, especially touch screens need a long-time focus but offer little feedback. In this paper, a new design of in-vehicle touchscreens’ interface system is proposed. The new design introduced the concept of multimodal (vision, auditory and haptic) and used sliding gestures to interaction. Auditory and haptic are fully utilized to transfer information and provide feedback, attempting to decrease the occupation of vision recourses when driving. This article also conducted a driving simulation experiment to make an evaluation of the design. Experiment data indicated that, the new design can realize eyes free without influencing the accuracy and completion time of secondary tasks, enhanced user experience meanwhile. This design will provide reference to the more intelligent and humanistic vehicle central control touchscreen.