Efficacy and safety of rosuvastatin and atorvastatin in aged patients with hypercholesterolemia

AIM To compare the efficacy and safety of rosuvastatin and atorvastatin in aged patients with hypercholesterolemia.METHODS After a 4-week dietary run-in period,a single-blinding,randomized cont- roled trial was conducted in 67 aged patients with LDL-C levels≥4.14 and≤6.50 mmol·L~(-1) and triglyceride (TG)levels≤4.52 mmol·L~(-1),which were randomized into rosuvastatin group(R group)and atorvastatin group(A group).Thirty-three patients in R group was treated with rosuvastatin 10 mg·d~(-1) and thirty-four patients in A group were administered with atorvastatin 20 mg·d~(-1) for 4 weeks,respectively.The efficacy and safety were observed.RESULTS The LDL-C level[(3.4±0.9) mmol·L~(-1) vs(2.8±0.8)mmol·L~(-1) in R group and(3.3±1.2)mmol·L~(-1)vs(2.4±0.7)mmol·L~(-1) in A group,P0.05]and TC level[(5.5±1.1) mmol·L~(-1) vs(4.8±0.9)mmol·L~(-1) in R group and(5.2±1.2) mmol·L~(-1)vs(4.5±0.6)mmol·L~(-1) in A group,P0.05] decreased significantly after 4 weeks treatment.TG and HDL-C levels before and after the treatment were no difference in both groups(P0.05).There was no significant difference between two groups(P0.05) .None of drug related SAE was found during the study.CONCLUSION Both rosuvastatin and atorvastatin are worthy of recommendation to aged patients with hypercholesterolemia.