瞬时受体电位通道
瘙痒的
TRPV1型
角化病
离子通道
皮肤病科
医学
转导(生物物理学)
受体
神经科学
生物
生物物理学
内科学
角化过度
作者
Gongxin Wang,Kewei Wang
出处
期刊:Molecular Pharmacology
[American Society for Pharmacology & Experimental Therapeutics]
日期:2017-04-04
卷期号:92 (3): 193-200
被引量:32
标识
DOI:10.1124/mol.116.107946
摘要
Temperature-sensitive transient receptor potential (TRP) channels such as TRPA1 and TRPV1 have been identified as downstream ion channel targets in the transduction of itch. As a member of the temperature-sensitive TRP family, the Ca2+-permeable nonselective cation channel TRPV3 is expressed abundantly in skin keratinocytes. Recent identification of gain-of-function mutations of human TRPV3 from patients with Olmsted syndrome, which is characterized by severe itching and palmoplantar and periorificial keratoderma, unveils its crucial role in chronic itch and skin diseases. In this review, we will focus on recent progress made in the understanding of TRPV3 that emerges as an attractive target for developing effective antipruritic therapy for chronic itch or skin-related diseases.
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