生物加工
免疫系统
串扰
计算机科学
生物
神经科学
工程类
免疫学
组织工程
遗传学
电子工程
作者
Robine Janssen,Laura Benito‐Zarza,Pim Cleijpool,Marta G. Valverde,Silvia M. Mihăilă,Shanna Bastiaan‐Net,Johan Garssen,Linette E. M. Willemsen,Rosalinde Masereeuw
标识
DOI:10.1002/adhm.202304569
摘要
Abstract Ever since the implementation of microfluidics in the biomedical field, in vitro models have experienced unprecedented progress that has led to a new generation of highly complex miniaturized cell culture platforms, known as Organs‐on‐a‐Chip (OoC). These devices aim to emulate biologically relevant environments, encompassing perfusion and other mechanical and/or biochemical stimuli, to recapitulate key physiological events. While OoCs excel in simulating diverse organ functions, the integration of the immune organs and immune cells, though recent and challenging, is pivotal for more comprehensive representation of human physiology. This comprehensive review covers the state of the art in the intricate landscape of immune OoC models, shedding light on the pivotal role of biofabrication technologies in bridging the gap between conceptual design and physiological relevance. We explore the multifaceted aspects of immune cell behavior, crosstalk and immune responses that are aimed to be replicated within microfluidic environments, emphasizing the need for precise biomimicry. Furthermore, we describe the latest breakthroughs and challenges of biofabrication technologies in immune OoC platforms, guiding researchers toward a deeper understanding of immune physiology and the development of more accurate and human predictive models for a.o., immune related disorders, immune development, immune programming, and immune regulation. This article is protected by copyright. All rights reserved
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