匹兹堡睡眠质量指数
原发性失眠
哈姆德
失眠症
医学
迷走神经电刺激
随机对照试验
麻醉
萧条(经济学)
睡眠障碍
治疗组和对照组
焦虑
物理疗法
刺激
睡眠质量
外科
内科学
迷走神经
精神科
经济
宏观经济学
作者
Yating Wu,Lu Song,Xian Wang,Ning Li,Shuqin Zhan,Peijing Rong,Yuping Wang,Aihua Liu
出处
期刊:Brain Sciences
[Multidisciplinary Digital Publishing Institute]
日期:2022-09-26
卷期号:12 (10): 1296-1296
被引量:30
标识
DOI:10.3390/brainsci12101296
摘要
(1) Background: The purpose of this study was to investigate the efficacy and safety of transcutaneous vagus nerve stimulation (t-VNS) in the treatment of primary insomnia. (2) Methods: This is a single center, randomized, double-blind study. A total of 30 patients diagnosed with primary insomnia were randomly divided into two groups to receive 20 Hz t-VNS in either the auricular concha area (treatment group) or periauricular area (control group), twice a day for 20 min during a one-month study period. The effective rate of treatment, defined as a ≥50% reduction of the Pittsburgh Sleep Index Scale (PSQI) after treatment, was compared between the two groups as the primary outcome. Response rate (defined as ≥10% change in the PSQI score), and changes in the Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scores were also assessed. (3) Results: After one month of treatment, the PSQI score of the treatment group decreased significantly (p = 0.001). The effective rate of the treatment group (73% vs. 27%, p = 0.027) was significantly higher than that of the control group. No statistical differences in changes of HAMA and HAMD scores were detected between the two groups. There were no complications in all patients. (4) Conclusion: T-VNS appeared to be a safe and effective treatment for primary insomnia.
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