Association Between Orthostatic Hypotension With Coronary Slow Flow in Patients With Chest Pain: A Single Center Experience

ABSTRACT Background Orthostatic hypotension (OH) is associated with different cardiovascular diseases, however, the association between OH and coronary slow flow (CSF) has never been evaluated before. Materials and Methods Chest pain patients who underwent coronary angiography (CAG) and with normal coronary arteries in our department from January 1st, 2022 to August 31st, 2023 were retrospectively enrolled. Patients were divided into the CSF group and the normal blood flow (NBF) group. Relative clinical information, laboratory test results as well as the results of CAG were collected and analyzed. Both uni‐variable and multi‐variable logistic regression analyses were used to evaluate the association between OH and CSF in these patients. Results Four thousand six hundred and twenty‐seven patients underwent CAG and 655 patients had normal coronary arteries. In which, sixty‐nine patients were diagnosed with CSF while 586 patients were diagnosed with NBF. Uni‐variable analysis revealed that higher body weight index, faster heart rate in sitting position, accompanied with chronic kidney disease, did not take Antidiabetic therapy, higher level of aspartate transaminase, uric acid, triglyceride, total cholesterol, ApoB1, low‐density lipoprotein cholesterol, homocysteine, B‐type natriuretic peptide as well as OH are the risk factors for CSF in these patients. Multi‐variable logistic regressing analysis further demonstrated that OH was the independent risk factor for predicting CSF in these patients. Conclusions Our finding suggests OH might be a useful predictor for CSF in patients with chest pain but normal coronary arteries.