FeS@LAB-35@Ti3C2 as a high-efficiency nanozyme for near infrared light induced photothermal enhanced chemodynamic antibacterial activity and wound healing

The abuse of antibiotics leads to a significant increase in bacterial resistance, which makes it difficult to treat bacterial infections. Therefore, it is urgent to develop new strategies for efficient antibacterial and wound healing. Recently, nanozymes based antibacterial agents have attracted increasing attention for their multifunction and high efficiency. In this study, we report a FeS@lauramidopropyl betaine (LAB-35)@Ti3C2 nanozyme as a high-efficiency antibacterial agent for near infrared (NIR) light induced photothermal enhanced chemodynamic antibacteria and wound healing. The FeS@LAB-35@Ti3C2 nanozyme possesses peroxidase-like catalysis activity, which can promote the generation of hydroxyl radicals (·OH) through catalyzing the decomposition of H2O2. FeS@LAB-35@Ti3C2 has photothermal conversion efficiency (η = 65.1%), and it exhibits enhanced catalytic activity under NIR light irradiation. The in vitro antibacterial experiments demonstrate the excellent antibacterial activity of FeS@LAB-35@Ti3C2 against representative Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. The animal experiments indicate that FeS@LAB-35@Ti3C2 nanozyme can effectively inhibit wound ulceration and promote wound healing. Overall, this study proposes FeS@LAB-35@Ti3C2 nanozyme that integrates chemodynamic and photothermal therapy, which provides an efficient strategy for bacterial inhibition and wound healing.