材料科学
免疫系统
免疫疗法
铁电性
细胞凋亡
纳米医学
细胞生物学
生物物理学
纳米技术
癌症研究
生物
免疫学
纳米颗粒
电介质
生物化学
光电子学
作者
Yaqian Du,Xudong Zhao,Fei He,H. Gong,Jiani Yang,Linzhi Wu,Xiaobing Cui,Shili Gai,Piaoping Yang,Jun Lin
标识
DOI:10.1002/adma.202403253
摘要
Abstract Low efficacy of immunotherapy due to the poor immunogenicity of most tumors and their insufficient infiltration by immune cells highlights the importance of inducing immunogenic cell death and activating immune system for achieving better treatment outcomes. Herein, ferroelectric Bi 2 CuO 4 nanoparticles (NPs) with rich copper vacancies (named BCO‐V Cu ) were rationally designed and engineered for ferroelectricity enhanced apoptosis, cuproptosis, and the subsequently evoked immunotherapy. In this structure, the suppressed recombination of the electron–hole pairs by the vacancies and the band bending by the ferroelectric polarization lead to high catalytic activiy, triggering reactive oxygen species bursts and inducing apoptosis. The cell fragments produced by apoptosis serve as antigens to activate T cells. Moreover, due to the generated charge by the ferroelectric catalysis, this nanomedicine can act as “a smart switch” to open the cell membrane, promote nanomaterial endocytosis, and shut down the Cu + outflow pathway to evoke cuproptosis, and thus a strong immune response is triggered by the reduced content of adenosine triphosphate. Ribonucleic acid transcription tests reveal the pathways related to immune response activation. Thus, our study firstly demonstrates a feasible strategy for enhancing the efficacy of immunotherapy using single ferroelectric semiconductor–induced apoptosis and cuproptosis. This article is protected by copyright. All rights reserved
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