A population pharmacokinetic screen to identify demographic-clinical covariates of basiliximab in liver transplantation

巴利昔单抗 医学 移植 人口 肝移植 内科学 胃肠病学 分配量 环孢素 药代动力学 泌尿科 外科 肾移植 环境卫生
作者
John M. Kovarik
出处
期刊:Clinical Pharmacology & Therapeutics [Wiley]
卷期号:69 (4): 201-209 被引量:48
标识
DOI:10.1067/mcp.2001.114887
摘要

Background Basiliximab is a high-affinity interleukin-2 receptor (CD25) chimeric monoclonal antibody used for immunoprophylaxis in organ transplantation. It was assessed in a randomized, double-blind, placebo-controlled efficacy trial in de novo liver allograft recipients who received 40 mg of basiliximab (20 mg on days 0 and 4) in addition to baseline immunosuppression with cyclosporine (INN, ciclosporin) microemulsion and corticosteroids. Methods Serial blood samples (8.3 ± 1.4 per patient) were collected during 12 weeks after transplantation from 184 basiliximab-treated patients, and empirical Bayes estimates of each patient's disposition parameters were derived. Demographic-clinical covariates were explored with regression methods. Results Basiliximab clearance was 55 ± 26 mL/h, the distribution volume was 9.7 ± 4.2 L, and the half-life was 8.7 ± 6.7 days. Patient weight, age, sex, ethnicity, history of alcoholism, hepatitis C seropositivity, and notable postoperative bleeding had no clinically relevant influences on basiliximab disposition; however, the cumulative volume of drained ascites fluid in the first week was positively correlated with clearance. Receptor-saturating basiliximab concentrations (≥0.1 μg/mL) were maintained for 38 ± 16 days, and this was negatively correlated with the cumulative volume of drained ascites fluid in week 1. Patients who experienced an acute rejection episode did not clear basiliximab at a faster rate than their rejection-free peers nor did they maintain CD25-saturating concentrations for a shorter period. Conclusions Although the standard dose regimen of 20 mg of basiliximab on days 0 and 4 after transplantation appears to be appropriate for the majority of patients with liver transplants, a supplemental dose at the end of the first week may be considered for those with substantial (>10 L) postoperative ascites fluid drainage. Clinical Pharmacology & Therapeutics (2001) 69, 201–209; doi: 10.1067/mcp.2001.114887
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