生物材料
Ⅰ型胶原
软骨
II型胶原
变性(裂变材料)
化学
组织工程
生物医学工程
材料科学
生物物理学
化学工程
纳米技术
解剖
核化学
病理
工程类
生物
医学
作者
Maria-Minodora Marin,Mǎdǎlina Georgiana Albu Kaya,George Mihail Vlăsceanu,Jana Ghițman,I. Radu,Horia Iovu
出处
期刊:Materiale Plastice
[Revista de Chimie SRL]
日期:2021-01-06
卷期号:57 (4): 166-180
被引量:5
标识
DOI:10.37358/mp.20.4.5416
摘要
Type II collagen has been perceived as the indispensable element and plays a crucial role in cartilage tissue engineering. Thus, materials based on type II collagen have drawn farther attention in both academic and research for developing new systems for the cartilage regeneration. The disadvantage of using type II collagen as a biomaterial for tissue repairing is its reduced biomechanical properties. This can be solved by physical, enzymatic or chemical cross-linking processes, which provide biomaterials with the required mechanical properties for medical applications. To enhance type II collagen properties, crosslinked collagen scaffolds with different cross-linking agents were prepared by freeze-drying technique. The present research work studied the synthesis of type II collagen biomaterials with and without crosslinking agents. Scaffolds morphology was observed by MicroCT, showing in all cases an appropriate microstructure for biological applications, and the mechanical studies were performed using compressive tests. DSC showed an increase in denaturation temperature with an increase in cross-linking agent concentration. FTIR suggested that the secondary structure of collagen is not affected after the cross-linking; supplementary, to confirm the characteristic triple-helix conformation of collagen, the CD investigation was performed. The results showed that the physical-chemical properties of type II collagen were improved by cross-linking treatments.
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