四面体
纳米技术
DNA纳米技术
核酸
DNA
生物相容性
药物输送
材料科学
化学
结晶学
生物化学
冶金
作者
Xiaolin Zhang,Nanxin Liu,Mi Zhou,Songhang Li,Xiaoxiao Cai
出处
期刊:Current stem cell research & therapy
[Bentham Science]
日期:2021-01-01
卷期号:16 (1): 48-56
被引量:9
标识
DOI:10.2174/1574888x15666200422103415
摘要
In recent years, tetrahedral Framework Nucleic Acids(tFNAs) have become a hot topic in the field of DNA nanostructures because of their stable structures, nanoscale size, superior mechanical properties and convenient synthesis with high yield. tFNAs are considered promising drug delivery carriers because they can pass through the cellular membrane without any help and they have a good biocompatibility and biodegradability. Besides, they have rich modification sites, they can be modified by kinds of functional groups. The functionalization molecules can be modified on the vertexes, embedded between the double-stranded DNA of the tetrahedron edges, hanged on the edges, or encapsulated in the cage-like structure of the tetrahedron. The structure of tetrahedron can also be intelligently controlled through smart design, such as integrating DNA hairpin loop structure onto the edges. Nowadays, DNA tetrahedron will have a broader development prospect in the application of drug transport carriers and intelligent drug carriers. Therefore, DNA material is a new carrier material with great advantages and has a very broad application prospect in the construction of an intelligent drug transport system.
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