癌症
胰腺癌
结直肠癌
表观遗传学
表观遗传学
食管癌
DNA甲基化
医学
癌症表观遗传学
癌症研究
肿瘤科
癌细胞
生物标志物
胃肠道癌
内科学
生物信息学
生物
胃肠道
瑞戈非尼
遗传学
基因
组蛋白甲基转移酶
基因表达
作者
William M. Grady,Ming Yu,Sanford D. Markowitz
标识
DOI:10.1053/j.gastro.2020.09.058
摘要
Colorectal cancer, liver cancer, stomach cancer, pancreatic cancer, and esophageal cancer are leading causes of cancer-related deaths worldwide. A fundamental trait of virtually all gastrointestinal cancers is genomic and epigenomic DNA alterations. Cancer cells acquire genetic and epigenetic alterations that drive the initiation and progression of the cancers by altering the molecular and cell biological processes of the cells. These alterations, as well as other host and microenvironment factors, ultimately mediate the clinical behavior of the precancers and cancers and can be used as biomarkers for cancer risk determination, early detection of cancer and precancer, determination of the prognosis of cancer and prediction of the response to therapy. Epigenetic alterations have emerged as one of most robust classes of biomarkers and are the basis for a growing number of clinical tests for cancer screening and surveillance.
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