胆汁淤积
肝损伤
医学
炎症体
纤维化
炎症
慢性肝病
急性肾损伤
肾脏疾病
病理
免疫学
内科学
肝硬化
作者
Mick Frissen,Lijun Liao,Kai Markus Schneider,Sonja Djudjaj,Johannes Haybaeck,Alexander Wree,Ulrike Rolle‐Kampczyk,Martin von Bergen�,Eicke Latz,Peter Boor,Christian Trautwein
出处
期刊：Hepatology
[Lippincott Williams & Wilkins]
日期：2020-08-04
卷期号：73 (5): 1836-1854
被引量：89
摘要
NLRP3 activation correlates with disease activity in patients with PBC. NLRP3 has a differential role during acute and chronic cholestatic liver injury in contrast to kidney injury. Disease progression during chronic cholestasis can be targeted through small molecules and thus suggests a potential clinical benefit for humans, attenuating liver and kidney injury.
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