Clinical Analysis of 29 Cases of Uterine Sarcoma

Objective To investigate the clinical characteristics,prognostic factors and the possibility to improve the treatment results of the uterine sarcoma.Methods Data of 29 patients with uterine sarcoma who were managed at the Sun Yat Sen Second affiliated hospital between 1990 and 2006 were analyzed retrospectively.Results 14 patients (48.28%) had leiomyosarcoma (LMS),11 patients (32.93%) had endometrial stromal sarcoma(ESS),3 patients (10.34%) had malignant mixed mullerian tumor (MMMT),and 1 patient had lymphosarcoma.22 patients had stage I disease,3 patients had stage II disease,2 patients had stage III and 1 patient had stage IV disease.There was no characteristic clinical features of uterine sarcoma,and definite diagnosis coule only be made preoperatively in 34.48% patients.Surgery ( abdominal hysterectomy and bilateralsalpingo-oophorectomy) was the main treatment,24(82.76%) patients received postoperative chemotherapy and 3(10.34%)patients received postoperative radiotherapy.The 2 and 5 year overall survival rates were 79.31% and 48.28%.Conclusion Uterine sarcomas are aggressive tumors with poor prognosis.There are no characteristic clinical features of the tumors.Surgical treatment consisting of radical hysterdctomy followed by adjuvant chemotherapy or radiotherapy can decrease the relapse and mortality rate.