Clinical and immunologic review analysis in 228 patients with vitiligo

Objective To evaluate various clinical characteristics and immunologic tests of vitiligo patients and probe the pathogenesis of vitiligo. Metheds Questionnaires and analysis were completed,which included all related factors on 228 cases of vitiligo.The serum levels of IgG antibodies to melanocyte,IL-6,IL-8 were measured in some patients with vitiligo. Results The results showed the peak of onset was 11 to 30 years old.Generalized vitiligo was in 38.9% patients.Autoimmune disease was showed in 5.7% vitiligo patients, and Family history of vitiligo was present in 4.8%. The serum levels of the antibody and all the cytokines in patients with progressive vitiligo were significantly higher than those normal individuals, and with stable disease except IL-6.The titer of antibody and the level of IL-8 in progressive extensive patients was significantly higher than that in progressive limitative patients. Conclusion Vitiligo is interrelated to autoimmune.