Interaction of ApoB Gene Polymorphisms and Environmental Factors in Bama' Longevity in Guangxi

Objective To investigate the interaction of the environmental factor of the longevity district and the genetic polymorphisms of ApoB in Bama longevity in Guangxi.Methods Genotyping of ApoB gene was performed by PCR-RFLP technique for 200 longevity people(aged 90-110) and 280 healthy controls(aged 48-89) from Bama county in Guangxi in May 2008.In the controls,140 samples from the longevity area were matched 140 samples from the no-longevity area for age and sex.All data were performed with logistic regression analysis.Results There were significant differences between longevity group and the control group in the frequencies of X+X-+X+X+ genotypes and X+ allele(P0.05).The X+X++X+X-genotypes and the environment of the longevity area contributed to a significantly higher possibility to be a longer life(the values of OR were 2.475 and 7.642) than did any one of the variant.It also showed a significant gene-environment interaction(OR=21.868;γ=1.513) of super-multiplicative model.Conclusion The polymorphisms of ApoB gene may be relevant to Bama's longevity in Guangxi.The environment of the longevity area is closely correlated with human longevity in Bama county.The polymorphisms of ApoB gene and the environment factor have a synergy in longevity in Bama.