Clinical observation of treatment with serial Jiangzhi Hugan capsule on nonalcoholic steatohepatitis

Objective:To observe the clinical effect of serial Jiangzhi Hugan capsule(JZHGC)on nonalcoholic steatohepatitis(NASH).Methods:One hundred patients in the treatment group were given JZHGCⅠ,Ⅱ and Ⅲ respectively on the basis of syndrome differentiation combined with disease differentiation;Sixty patients in the control group was treated with tabellae inositoli nicotinatis and glucuro lactone tablets.After they were treated for 8 weeks without other drugs for protecting liver function,reducing aminotransferase and lowering lipid.Changes of ALT,AST,TCh,TG,PⅢP,LN,HA,Ⅳ-C,B-ultrasound,CT,clinical symptoms and signs before and after treatment were observed.Results:The distinct effective rate in the treatment group and in the control group were 65% and 35% respectively(P 0.01);The total effective rate in the treatment group and in the control group were 94% and 58.3 %respectively;There were also significant differences in ALT,GGT,TCh,TG between the two groups after treatment(P 0.01).After treatment,changes of biochemical items such as ALT,AST,TBil,TCh,TG,PⅢP,LN,HA,Ⅳ-C in the treatment group were significant(P 0.01).Conclusion: JZHGC can protect liver function,reduce aminotransferase and treat liver fibrosis.