The water up-take sources of a city is mainly polluted by organic pollutants and high weight metals. However,the removal efficiency of organic pollutants and high weight metals is extremely low when using normal drinking water treatment processes. Therefore,The reverse osmosis(RO) system was chosen for the advanced treatment of drinking water according to the water sources quality of this city. The run results of two years showed that the removal efficiency of organic pollutants,high weight metals and bacteria is very high after RO system.