吞噬作用
吞噬体
生物
自噬
微生物学
细胞生物学
细胞质
细胞凋亡
生物化学
作者
Marc Herb,Alexander Gluschko,Michael Schramm
标识
DOI:10.1016/j.semcdb.2019.04.016
摘要
Phagocytes ingest, kill and degrade invading microbes in a process called phagocytosis. LC3-associated phagocytosis (LAP) combines the molecular machinery of phagocytosis with that of autophagy, the cellular pathway for ingestion of cytoplasmic components, resulting in the eponymous association of ‘microtubule-associated proteins 1 A/1B light chain 3’ (LC3) with the phagosomal membrane. The LC3-decorated phagosomes, or LAPosomes, show enhanced fusion with lysosomes resulting in enhanced killing and degradation of contained pathogens. Thus, LAP is a particularly microbicidal pathway. In this review, we discuss the molecular mechanisms involved in induction and execution of LAP and its crucial role in antimicrobial immunity against bacteria, fungi and parasites. As LAP has only recently been defined, we also point out the key open questions that remain to be answered.
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