Back Cover: A Biomimetic Approach for Spatially Controlled Cell Membrane Engineering Using Fusogenic Spherical Nucleic Acid (Angew. Chem. Int. Ed. 1/2022)

Fusion of extracellular vesicles to cells contributes to many critical biological pathways. Inspired by the natural fusion process, Hang Xing and co-workers developed a liposome fusion-based transport strategy, termed LiFT, that enables the incorporation of a variety of functional moieties onto both external and internal cell membrane surfaces with precise orientation control (e202111647). By using LiFT, asymmetric DNA modifications with orthogonal functionalities on each side of the cell membrane were achieved, realizing applications such as heterotypic cell assembly and intracellular metabolite detection.