Acidic polysaccharides from Buddleja officinalis inhibit angiogenesis via the Nrf2/ARE pathway to attenuate diabetic retinopathy

mechanistic experiments, the generation of ROS was inhibited after APBOM intervention, and the expression of CD34, CD31 and VEGF was decreased. Furthermore, the mRNA and protein levels of HO-1, NQO1, SOD and Nrf2 were increased, which indicated that APBOM might promote expression of the Nrf2/ARE signaling pathway. Overall, APBOM might alleviate DR by inhibiting angiogenesis and activating the Nrf2/ARE signaling pathway.