Clinical, histopathological and prognostic features of primary cutaneous acral CD8 + T‐cell lymphoma and other dermal CD8 + cutaneous lymphoproliferations: results of an EORTC Cutaneous Lymphoma Group workshop*

A constellation of distinct clinical, histopathological and phenotypic features allows discrimination and assignment of dermal CD8⁺ infiltrates into distinct disease entities. Primary cutaneous acral CD8⁺ lymphoma, assigned a provisional category in current lymphoma classifications, is a distinct and reproducible entity. A correct diagnosis is essential to avoid unnecessarily aggressive treatment for indolent CD8⁺ lymphoproliferations and to identify cases with underlying immuno-deficiency or potential for dismal outcome.