Postsynthetic Modification of Peptides: Chemoselective C‐Arylation of Tryptophan Residues

Born to be mild: The general, direct and selective C2 arylation of native Trp-containing peptides can be achieved by palladium-catalyzed CH activation with aryl iodides in water, under microwave irradiation for a short time (see scheme). Under these mild conditions, the structural and stereochemical integrity of peptides is preserved. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.