药品
药剂学
体外
木糖醇
药理学
口香糖
剂型
体内
化学
医学
食品科学
生物
生物技术
生物化学
发酵
作者
Catharina Kvist,Sven Börje Andersson,Susan Fors,Bo Wennergren,Johan Berglund
标识
DOI:10.1016/s0378-5173(99)00236-7
摘要
An apparatus for in vitro drug release testing of medicated chewing gums has been developed and is described in detail. The effects on the drug release when varying critical instrumental settings such as the chewing stroke frequency, the distance between the chewing surfaces, the twisting movements of these surfaces and the temperature of the test medium have been thoroughly investigated. It has been shown that the drug release can be tuned to obtain suitable drug release profiles for a number of products: Nicorette((R)) and Nicotinell((R)) (active substance nicotine), Travvell((R)) (dimenhydrinate), V6((R)) (xylitol) and an experimental formulation containing meclizine. The main usage of the present apparatus should be within quality control but the present study has also shown that it may be employed within development pharmaceutics since useful in vivo/in vitro relationships may be obtained due to the versatile settings of the critical instrumental parameters.
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