Mycosis fungoides/Sézary syndrome is frequently misdiagnosed, leading to treatment delays and potential harm in the era of immunomodulatory therapies. We present the ‘A–F Think MF’ acronym, a practical, easy-to-remember clinical tool designed to aid dermatologists in recognizing subtle features suggestive of cutaneous T-cell lymphoma. This perspective highlights the urgency of early recognition and aims to enhance diagnostic vigilance in everyday dermatology practice.