AAnet Resolves a Continuum of Spatially Localized Cell States to Unveil Intratumoral Heterogeneity

Defining critical cell states among cells that reside along a phenotypic continuum is a current biological and computational challenge. In this study, we present AAnet, a neural network that learns archetypal cell states of cancer cells. AAnet defines discrete spatially localized ATs that resolve intratumoral heterogeneity.