N‐2‐hydroxypropyl trimethyl ammonium chloride chitosan‐glycerol complex temperature‐sensitive hydrogel for wound dressing

Abstract With the development of the times, it becomes difficult or even impossible for traditional wound dressings to meet people's needs for high‐quality wound repair and management. Therefore, there is an urgent need for new biomedical dressings that can accelerate wound healing in clinical practice. In this study, N‐2‐hydroxypropyl trimethylammonium chloride chitosan (N‐2‐HACC), a derivative of chitosan, was used as raw material to sprepare N‐2‐HACC temperature sensitive hydrogel. The structure, thermal stability and water content of N‐2‐HACC temperature sensitive hydrogel were analyzed by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. The safety of N‐2‐HACC temperature sensitive hydrogel was evaluated by in vitro cell assay and in vitro degradation assay, and the effect of N‐2‐HACC temperature sensitive hydrogel on wound healing was evaluated by wound healing experiment in SD rats. The results show that N‐2‐HACC hydrogel, as a wound dressing, has the characteristics of good biocompatibility, good biodegradation, non‐toxic, anti‐inflammatory and so on. It plays a barrier role in the process of wound healing, provides a moist environment for the wound and accelerates wound healing. Therefore, N‐2‐HACC hydrogel has a broad application prospect in promoting wound healing as a wound dressing.