细胞生物学
成纤维细胞生长因子
血管生成
上皮-间质转换
牙髓干细胞
间充质干细胞
化学
干细胞
平衡
自噬
坏死性下垂
癌症研究
医学
生物
下调和上调
程序性细胞死亡
细胞凋亡
生物化学
受体
基因
作者
Wenjie Lu,Juan Zhao,Xiong Chen,Yutian Wang,Wen-Wei Lin,Yingcui Fang,Yunyang Wang,Junping Ao,Jianyong Shou,Jiake Xu,Shoutian Zhu
标识
DOI:10.1016/j.mtbio.2023.100919
摘要
Diabetes causes a loss of sensation in the skin, so diabetics are prone to burns when using heating devices. Diabetic scalded skin is often difficult to heal due to the microenvironment of high glucose, high oxidation, and low blood perfusion. The treatment of diabetic scald mainly focuses on three aspects: 1) promote the formation of the epithelium; 2) promote angiogenesis; and 3) maintain intracellular homeostasis. In response to these three major repair factors, we developed a cadherin-responsive hydrogel combined with FGF21 and dental pulp stem cells (DPSCs) to accelerate epithelial formation by recruiting cadherin to the epidermis and promoting the transformation of N cadherin to E cadherin; promoting angiogenesis to increase wound blood perfusion; regulating the stability of lysosomal and activating autophagy to maintain intracellular homeostasis in order to comprehensively advance the recovery of diabetic scald.
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