HyMNet: A Multimodal Deep Learning System for Hypertension Prediction Using Fundus Images and Cardiometabolic Risk Factors

STUDY OBJECTIVES: This study aimed to develop a multimodal deep learning (MMDL) system called HyMNet, integrating fundus images and cardiometabolic factors (age and sex) to enhance hypertension (HTN) detection. METHODS: HyMNet employed RETFound, a model pretrained on 1.6 million retinal images, for the fundus data, in conjunction with a fully connected neural network for age and sex. The two pathways were jointly trained by joining their feature vectors into a fusion network. The system was trained on 5016 retinal images from 1243 individuals provided by the Saudi Ministry of National Guard Health Affairs. The influence of diabetes on HTN detection was also assessed. RESULTS: HyMNet surpassed the unimodal system, achieving an F1 score of 0.771 compared to 0.745 for the unimodal model. For diabetic patients, the F1 score was 0.796, while it was 0.466 for non-diabetic patients. CONCLUSIONS: HyMNet exhibited superior performance relative to unimodal approaches, with an F1 score of 0.771 for HyMNet compared to 0.752 for models trained on demographic data alone, underscoring the advantages of MMDL systems in HTN detection. The findings indicate that diabetes significantly impacts HTN prediction, enhancing detection accuracy among diabetic patients. Utilizing MMDL with diverse data sources could improve clinical applicability and generalization.